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General Medicine · Neurology: subarachnoid haemorrhage
Sample itemA 40-year-old woman has a sudden severe headache, 'the worst of her life', with neck stiffness. A non-contrast CT head done 18 hours after onset is normal. What is the next step?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Lumbar puncture, looking for xanthochromia
CT within 6 hours of onset is highly sensitive for subarachnoid haemorrhage but loses sensitivity with time. If suspicion remains and CT is negative or delayed, lumbar puncture performed at least 12 hours after onset can show xanthochromia from bilirubin. A confirmed bleed is followed by CT or catheter angiography, nimodipine and aneurysm securing.
Option by option
A. Lumbar puncture, looking for xanthochromia (correct)
Correct. Xanthochromia in CSF can detect blood missed by a late CT.
B. Start intravenous heparin
Heparin could worsen bleeding.
C. Repeat the CT after one week
A week's delay risks fatal rebleeding.
D. Discharge with analgesics because CT is normal
A normal CT beyond 6 hours does not exclude haemorrhage in this setting.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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