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General Medicine · Nephrology: uraemic pericarditis
Sample itemA 48-year-old man with end-stage kidney disease who missed several dialysis sessions has pleuritic chest pain and a pericardial friction rub. Urea is 210 mg/dL. Echocardiography shows a small effusion without tamponade. What is the best treatment?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Urgent intensive haemodialysis with minimal or no heparin
Uraemic pericarditis is an indication for dialysis, and it usually resolves with daily or intensified sessions. Heparin is minimised to avoid haemorrhagic effusion. Pericardiocentesis or a window is reserved for tamponade or an effusion that persists despite intensive dialysis.
Option by option
A. Intravenous thrombolysis
Thrombolysis is contraindicated and would risk haemorrhagic effusion.
B. Urgent intensive haemodialysis with minimal or no heparin (correct)
Correct. Removing uraemic toxins treats the cause, and heparin is limited to prevent haemopericardium.
C. Immediate pericardiocentesis
Pericardiocentesis is needed only for tamponade, and none is present here.
D. Anticoagulation with therapeutic heparin
Heparin increases the risk of bleeding into the pericardium.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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