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Radiology · Radiotherapy and nuclear medicine basics: Lhermitte sign
Sample itemThree months after mantle-field radiotherapy for Hodgkin lymphoma, a patient reports electric-shock sensations down the spine on neck flexion. Examination and MRI are normal, and the symptom settles over several months. What is the cause?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Transient radiation myelopathy from demyelination
Lhermitte sign appearing weeks to months after cervical-cord irradiation reflects transient demyelination, resolves spontaneously and does not predict permanent myelopathy. Chronic progressive radiation myelopathy appears after months to years with fixed deficits and cord changes. Recovery with a normal MRI argues against a structural lesion.
Option by option
A. Permanent radiation myelitis with cord necrosis
Permanent myelitis causes progressive fixed deficits and MRI changes.
B. Spinal cord metastasis
A metastasis would produce a visible lesion and progressive deficits.
C. Syringomyelia
A syrinx would be seen on MRI and gives dissociated sensory loss.
D. Transient radiation myelopathy from demyelination (correct)
Correct. Self-limited demyelination causes the transient shock sensations.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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