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Radiology · Radiotherapy and nuclear medicine basics: brain death scintigraphy
Sample itemIn a ventilated patient with suspected brain death, apnoea testing cannot be completed. A Tc-99m HMPAO study shows no intracranial uptake, with scalp and facial uptake preserved. What does this indicate?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Absent intracerebral perfusion, supporting brain death
A radionuclide perfusion study in brain death shows no uptake in the brain parenchyma while the scalp and face still take up the tracer, which gives a hollow-skull appearance. It is an ancillary test that supports the clinical diagnosis when clinical testing is incomplete. It does not replace clinical certification.
Option by option
A. Absent intracerebral perfusion, supporting brain death (correct)
Correct. Absent cerebral uptake with preserved scalp uptake supports brain death.
B. Cerebral hyperperfusion from encephalitis
Encephalitis typically increases uptake in affected regions.
C. Perfusion loss limited to a prior stroke
A prior stroke gives a regional defect, not global absence.
D. Normal perfusion with a technical failure
Normal perfusion would show brain uptake.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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