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Radiology · Chest and cardiac imaging: pulmonary alveolar microlithiasis
Sample itemAn asymptomatic young adult with a family history of similar findings has a chest radiograph showing innumerable tiny sand-grain calcific densities in both lungs, denser at the bases, obscuring the heart borders. What is the diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Pulmonary alveolar microlithiasis
Pulmonary alveolar microlithiasis is an autosomal recessive condition with calcium phosphate microliths filling the alveoli, producing a sandstorm appearance. Symptoms are often mild compared with the striking radiograph. Miliary TB nodules are larger, non-calcified and the patient is unwell.
Option by option
A. Simple silicosis
Silicosis gives small nodules in the upper zones and needs an exposure history.
B. Miliary tuberculosis
Miliary TB gives uniform 1 to 3 mm non-calcified nodules in a febrile patient.
C. Pulmonary alveolar microlithiasis (correct)
Correct. Diffuse, tiny, calcified densities in an asymptomatic person suggest microlithiasis.
D. Pulmonary sarcoidosis
Sarcoidosis gives hilar adenopathy and perilymphatic nodules, not dense calcific sand.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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