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Dermatology · Infections: bacterial, viral, fungal, parasitic: bullous scabies mimicking pemphigoid
Sample itemAn 80-year-old man has tense blisters on the arms and thighs with severe nocturnal itch. His wife is also itchy, and small burrows are seen in the finger webs. What is the most appropriate management?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Topical permethrin for him and his household contacts
Bullous scabies can closely mimic bullous pemphigoid in the elderly. Burrows, nocturnal itch and itching in a close contact point to scabies, which is treated with a scabicide for the patient and all household contacts. Immunosuppression for a presumed autoimmune disease would worsen the infestation.
Option by option
A. Oral prednisolone at high dose for pemphigoid
High-dose steroid assumes an autoimmune blistering disease and would aggravate infestation.
B. Topical clobetasol propionate alone
Topical steroid alone suppresses inflammation but leaves the mites untreated and the contacts infested.
C. Topical permethrin for him and his household contacts (correct)
Correct. Scabicide treatment of the patient and contacts treats the cause, and the blisters resolve with it.
D. Oral dapsone alone for dermatitis herpetiformis
Dapsone targets dermatitis herpetiformis, which is not suggested by burrows and a household itch.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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