Vesiculobullous disorders: monitoring pemphigus by ELISA: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Dermatology · Vesiculobullous disorders: monitoring pemphigus by ELISA

Sample item

A man with pemphigus vulgaris in remission is followed in clinic. Which laboratory test best tracks disease activity and may predict relapse?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. ELISA for anti-desmoglein antibody titres

Serum anti-desmoglein 1 and 3 titres by ELISA correlate with disease activity in pemphigus and are used to follow response and anticipate relapse. They are an adjunct and do not replace clinical assessment.

Option by option

  • A. ELISA for anti-desmoglein antibody titres (correct)

    Correct. Anti-Dsg1 and Dsg3 ELISA titres follow disease activity.

  • B. Serum IgE level

    IgE is raised in atopy and bullous pemphigoid, not a measure of pemphigus activity.

  • C. Antinuclear antibody titre

    ANA is used in connective tissue disease and does not track pemphigus.

  • D. Anti-streptolysin O titre

    ASO titre reflects recent streptococcal infection.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Dermatology questions

Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is A, ELISA for anti-desmoglein antibody titres. Serum anti-desmoglein 1 and 3 titres by ELISA correlate with disease activity in pemphigus and are used to follow response and anticipate relapse.

Why is "Serum IgE level" not the answer?

IgE is raised in atopy and bullous pemphigoid, not a measure of pemphigus activity.

Why is "Antinuclear antibody titre" not the answer?

ANA is used in connective tissue disease and does not track pemphigus.

Why is "Anti-streptolysin O titre" not the answer?

ASO titre reflects recent streptococcal infection.

What concept does this question test?

It tests Vesiculobullous disorders: monitoring pemphigus by ELISA in Dermatology. They are an adjunct and do not replace clinical assessment.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vesiculobullous disorders: monitoring pemphigus by ELISA?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.