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Dermatology · STI: recurrent versus primary genital herpes
Sample itemHow does a recurrent episode of genital herpes differ from the first primary episode?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Fewer lesions that heal faster, usually with a prodrome and no systemic symptoms
Recurrences are milder because antibody and cell-mediated immunity are present. Lesions are fewer, heal in about a week, are often preceded by itching or tingling, and systemic features are absent.
Option by option
A. More extensive lesions with fever and bilateral lymphadenopathy
Extensive lesions with fever and bilateral nodes describe the primary episode.
B. Lesions that last longer, with viral shedding for several weeks
Longer lesions with weeks of viral shedding describe a primary episode.
C. Painless indurated ulcers with persistent lymph node enlargement
Painless indurated ulcers describe syphilis, not herpes.
D. Fewer lesions that heal faster, usually with a prodrome and no systemic symptoms (correct)
Correct. Recurrences are milder, shorter and preceded by a prodrome.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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