Skin tumours: hereditary leiomyomatosis and renal cell cancer: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Skin tumours: hereditary leiomyomatosis and renal cell cancer

Sample item

A woman with multiple painful grouped red-brown cutaneous papules (leiomyomas) also has early-onset uterine fibroids. Which screening is most important?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Periodic renal imaging for renal cell carcinoma

Multiple cutaneous leiomyomas with uterine fibroids suggest hereditary leiomyomatosis and renal cell cancer from fumarate hydratase mutation. Affected people have an increased risk of aggressive renal cell carcinoma, so periodic renal imaging is advised.

Option by option

  • A. Colonoscopy for polyposis

    Colonoscopy is advised in syndromes such as Peutz-Jeghers or Muir-Torre, not in this one.

  • B. Thyroid ultrasound for medullary carcinoma

    Thyroid ultrasound is advised in conditions such as Cowden syndrome or MEN 2, not in this one.

  • C. Brain MRI for glioma

    Brain MRI is advised in conditions such as neurofibromatosis type 2, not in this one.

  • D. Periodic renal imaging for renal cell carcinoma (correct)

    Correct. Fumarate hydratase mutation carries a high risk of renal cell carcinoma.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is D, Periodic renal imaging for renal cell carcinoma. Multiple cutaneous leiomyomas with uterine fibroids suggest hereditary leiomyomatosis and renal cell cancer from fumarate hydratase mutation.

Why is "Colonoscopy for polyposis" not the answer?

Colonoscopy is advised in syndromes such as Peutz-Jeghers or Muir-Torre, not in this one.

Why is "Thyroid ultrasound for medullary carcinoma" not the answer?

Thyroid ultrasound is advised in conditions such as Cowden syndrome or MEN 2, not in this one.

Why is "Brain MRI for glioma" not the answer?

Brain MRI is advised in conditions such as neurofibromatosis type 2, not in this one.

What concept does this question test?

It tests Skin tumours: hereditary leiomyomatosis and renal cell cancer in Dermatology. Affected people have an increased risk of aggressive renal cell carcinoma, so periodic renal imaging is advised.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Skin tumours: hereditary leiomyomatosis and renal cell cancer?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.