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ENT · Head and neck tumours: lymphoma in Sjogren syndrome
Sample itemA 55-year-old woman with long-standing Sjogren syndrome develops rapid, firm, painless enlargement of one parotid gland. Which complication is most likely?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Marginal zone (MALT) B-cell lymphoma
Sjogren syndrome carries a markedly increased risk of extranodal marginal zone (MALT) lymphoma, particularly in the parotid. Persistent firm, asymmetric enlargement, new lymphadenopathy or purpura in a patient with Sjogren syndrome should prompt a biopsy.
Option by option
A. Acinic cell carcinoma
Acinic cell carcinoma is a rare epithelial tumour without this link.
B. Warthin tumour
Warthin tumour is not linked to Sjogren syndrome.
C. Marginal zone (MALT) B-cell lymphoma (correct)
Correct. Chronic lymphoepithelial inflammation predisposes to MALT lymphoma.
D. Sialolithiasis
A stone would cause painful meal-related swelling.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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