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General Medicine · Respiratory medicine: aspergilloma
Sample itemA 45-year-old man with old cavitary tuberculosis has recurrent haemoptysis. The radiograph shows a mobile round mass within an upper-lobe cavity, separated from the wall by a crescent of air, and serum Aspergillus precipitins are positive. What is the most likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Aspergilloma
A fungal ball of Aspergillus colonises a pre-existing cavity such as old tuberculosis or sarcoid. It moves with posture, causes an air-crescent sign and gives recurrent haemoptysis. Massive bleeding may need bronchial artery embolisation or resection.
Option by option
A. Aspergilloma (correct)
Correct. A mobile intracavitary mass with an air crescent and positive precipitins is an aspergilloma.
B. Lung abscess
A lung abscess has an air-fluid level and a thick wall, without a mobile ball.
C. Cavitating squamous carcinoma
A cavitating carcinoma has a thick irregular wall and does not move with posture.
D. Reactivation of tuberculosis
Reactivation of tuberculosis would not produce a mobile intracavitary mass.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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