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General Medicine · Gastroenterology and hepatology: giardiasis
Sample itemA trekker returns with 2 weeks of foul-smelling, greasy pale stools, bloating and flatulence, without fever or blood. Stool microscopy shows pear-shaped flagellated trophozoites with a sucking disc. Which drug is appropriate?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Tinidazole
Giardia lamblia is acquired by cysts in contaminated water and causes malabsorptive diarrhoea. Nitroimidazoles such as tinidazole (a single dose) or metronidazole are effective. It is more severe in people with IgA deficiency.
Option by option
A. Tinidazole (correct)
Correct. Tinidazole is a nitroimidazole active against Giardia.
B. Praziquantel
Praziquantel treats trematodes and cestodes, not protozoa.
C. Albendazole
Albendazole acts on helminths and not protozoa.
D. Ciprofloxacin
Ciprofloxacin does not treat protozoal infection.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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