Complications of pregnancy: misoprostol embryopathy: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Complications of pregnancy: misoprostol embryopathy

Sample item

A woman used misoprostol at 6 weeks in an unsuccessful attempt to end her pregnancy. The child is born with facial nerve paralysis, an expressionless face, inability to abduct the eyes and limb defects. Which condition is this?

AMoebius sequenceBGoldenhar syndromeCPierre Robin sequenceDTreacher Collins syndrome

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Moebius sequence

First-trimester misoprostol exposure, probably by uterine contractions causing vascular disruption, is linked with Moebius sequence (cranial nerve VI and VII palsies) and limb reduction defects. Women should be counselled about the risk when the abortion fails.

Option by option

A. Moebius sequence (correct)
Correct. Congenital VI and VII nerve palsies with limb defects after misoprostol exposure form the Moebius sequence.
B. Goldenhar syndrome
Goldenhar syndrome has hemifacial microsomia with epibulbar dermoids and vertebral anomalies.
C. Pierre Robin sequence
Pierre Robin sequence consists of micrognathia, glossoptosis and cleft palate.
D. Treacher Collins syndrome
Treacher Collins is an inherited mandibulofacial dysostosis with downslanting palpebral fissures.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this OBG question

What is the answer to this OBG question?

The best answer is A, Moebius sequence. First-trimester misoprostol exposure, probably by uterine contractions causing vascular disruption, is linked with Moebius sequence (cranial nerve VI and VII palsies) and limb reduction defects.

Why is "Goldenhar syndrome" not the answer?

Goldenhar syndrome has hemifacial microsomia with epibulbar dermoids and vertebral anomalies.

Why is "Pierre Robin sequence" not the answer?

Pierre Robin sequence consists of micrognathia, glossoptosis and cleft palate.

Why is "Treacher Collins syndrome" not the answer?

Treacher Collins is an inherited mandibulofacial dysostosis with downslanting palpebral fissures.

What concept does this question test?

It tests Complications of pregnancy: misoprostol embryopathy in OBG. Women should be counselled about the risk when the abortion fails.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Complications of pregnancy: misoprostol embryopathy?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.