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OBG · Postpartum haemorrhage and emergencies: antibiotics for postpartum endometritis
Sample itemOn day 3 after a caesarean following prolonged labour, a woman has temperature 39 degrees C, uterine tenderness and foul lochia. Which regimen is standard first-line?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Intravenous clindamycin plus gentamicin
Postpartum endometritis is polymicrobial, with aerobes and anaerobes, and needs broad-spectrum intravenous treatment. Clindamycin with gentamicin is a standard regimen, continued until the woman is afebrile for about 24 to 48 hours.
Option by option
A. Oral ciprofloxacin alone
Oral ciprofloxacin alone lacks reliable anaerobic and streptococcal cover and is a poor choice.
B. Intravenous metronidazole alone
Metronidazole alone covers anaerobes only.
C. Oral amoxicillin alone
Oral amoxicillin alone lacks adequate gram-negative and anaerobic cover for this infection.
D. Intravenous clindamycin plus gentamicin (correct)
Correct. Clindamycin covers anaerobes and gentamicin covers gram-negative aerobes.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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