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OBG · Hypertensive disorders: neonate after maternal magnesium
Sample itemA baby delivered after the mother received magnesium sulphate for 24 hours for severe pre-eclampsia is floppy with depressed respiration. Which explanation is most likely?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Neonatal magnesium toxicity
Magnesium crosses the placenta, so the neonate can have hypotonia, a poor suck and respiratory depression, which are usually transient. Supportive care is given, with monitoring of serum magnesium if needed.
Option by option
A. Birth asphyxia
Asphyxia would be accompanied by a history of fetal distress or low Apgar scores at birth.
B. Neonatal magnesium toxicity (correct)
Correct. Placental transfer of magnesium causes neonatal hypotonia and respiratory depression.
C. Neonatal hypoglycaemia due to maternal diabetes
The mother's diagnosis was pre-eclampsia, and diabetes is not mentioned.
D. Neonatal sepsis
Sepsis is possible but the history of prolonged magnesium therapy gives a direct explanation.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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