Gynaecological endocrinology: autoimmune primary ovarian insufficiency: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

OBG · Gynaecological endocrinology: autoimmune primary ovarian insufficiency

Sample item

A 27-year-old has primary ovarian insufficiency with a normal karyotype and normal fragile X premutation testing. Which additional screening is most important?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Adrenal (21-hydroxylase) antibodies

A proportion of idiopathic POI is autoimmune and may be linked to autoimmune adrenal insufficiency. Adrenal cortex or 21-hydroxylase antibodies identify women at risk of Addison disease, which can be life threatening if missed.

Option by option

  • A. Adrenal (21-hydroxylase) antibodies (correct)

    Correct. Adrenal antibodies identify women at risk of autoimmune Addison disease.

  • B. Antinuclear antibody titre

    ANA is not a standard screening test for POI.

  • C. Anti-thyroid antibodies in her mother

    Testing the mother does not guide care for the patient.

  • D. Antiphospholipid antibodies

    Antiphospholipid antibodies are tested in recurrent pregnancy loss or thrombosis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is A, Adrenal (21-hydroxylase) antibodies. A proportion of idiopathic POI is autoimmune and may be linked to autoimmune adrenal insufficiency.

Why is "Antinuclear antibody titre" not the answer?

ANA is not a standard screening test for POI.

Why is "Anti-thyroid antibodies in her mother" not the answer?

Testing the mother does not guide care for the patient.

Why is "Antiphospholipid antibodies" not the answer?

Antiphospholipid antibodies are tested in recurrent pregnancy loss or thrombosis.

What concept does this question test?

It tests Gynaecological endocrinology: autoimmune primary ovarian insufficiency in OBG. Adrenal cortex or 21-hydroxylase antibodies identify women at risk of Addison disease, which can be life threatening if missed.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological endocrinology: autoimmune primary ovarian insufficiency?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.