Inflammation and repair: P-selectin mobilisation: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Inflammation and repair: P-selectin mobilisation

Sample item

Within minutes of exposure to histamine, venular endothelium shows a marked increase in leukocyte rolling. Which change at the endothelial surface explains this rapid response?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Redistribution of P-selectin from Weibel-Palade bodies to the surface

Mediators such as histamine and thrombin cause P-selectin stored in Weibel-Palade bodies to move to the endothelial surface within minutes. E-selectin and ICAM-1 appear later, over one to two hours, when IL-1 and TNF induce their transcription. Selectins bind sialylated oligosaccharides on leukocytes to slow them.

Option by option

  • A. Shedding of L-selectin from the endothelium

    L-selectin is expressed on leukocytes, not on endothelium.

  • B. Increased affinity of integrins for ICAM-1

    Integrin affinity changes occur on leukocytes, mediated by chemokines, after rolling.

  • C. Redistribution of P-selectin from Weibel-Palade bodies to the surface (correct)

    Correct. Stored P-selectin is mobilised within minutes without new synthesis.

  • D. New transcription of E-selectin through NF-kB

    E-selectin needs gene transcription and appears after one to two hours.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Redistribution of P-selectin from Weibel-Palade bodies to the surface. Mediators such as histamine and thrombin cause P-selectin stored in Weibel-Palade bodies to move to the endothelial surface within minutes.

Why is "Shedding of L-selectin from the endothelium" not the answer?

L-selectin is expressed on leukocytes, not on endothelium.

Why is "Increased affinity of integrins for ICAM-1" not the answer?

Integrin affinity changes occur on leukocytes, mediated by chemokines, after rolling.

Why is "New transcription of E-selectin through NF-kB" not the answer?

E-selectin needs gene transcription and appears after one to two hours.

What concept does this question test?

It tests Inflammation and repair: P-selectin mobilisation in Pathology. E-selectin and ICAM-1 appear later, over one to two hours, when IL-1 and TNF induce their transcription. Selectins bind sialylated oligosaccharides on leukocytes to slow them.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation and repair: P-selectin mobilisation?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.