Inflammation and repair: Hageman factor: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Inflammation and repair: Hageman factor

Sample item

Which plasma protein, activated on contact with exposed collagen or basement membrane, initiates the kinin, clotting and fibrinolytic systems at a site of injury?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Hageman factor (factor XII)

Hageman factor (factor XII) is activated by contact with negatively charged surfaces such as exposed collagen. It starts the kinin system, which produces bradykinin, and the clotting and fibrinolytic cascades, linking inflammation with coagulation. Kallikrein generated in the process also amplifies the cascade.

Option by option

  • A. Hageman factor (factor XII) (correct)

    Correct. Factor XII is the contact-activated link between these plasma systems.

  • B. Factor VIII

    Factor VIII is a cofactor of the intrinsic tenase complex and does not initiate contact activation.

  • C. Protein C

    Protein C is an anticoagulant that inactivates factors Va and VIIIa.

  • D. Factor XIII

    Factor XIII cross-links fibrin and acts at the end of coagulation.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is A, Hageman factor (factor XII). Hageman factor (factor XII) is activated by contact with negatively charged surfaces such as exposed collagen.

Why is "Factor VIII" not the answer?

Factor VIII is a cofactor of the intrinsic tenase complex and does not initiate contact activation.

Why is "Protein C" not the answer?

Protein C is an anticoagulant that inactivates factors Va and VIIIa.

Why is "Factor XIII" not the answer?

Factor XIII cross-links fibrin and acts at the end of coagulation.

What concept does this question test?

It tests Inflammation and repair: Hageman factor in Pathology. It starts the kinin system, which produces bradykinin, and the clotting and fibrinolytic cascades, linking inflammation with coagulation. Kallikrein generated in the process also amplifies the cascade.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation and repair: Hageman factor?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.