Inflammation and repair: eotaxin: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Inflammation and repair: eotaxin

Sample item

In allergic inflammation of the airway, which chemokine acts through CCR3 to recruit eosinophils selectively?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Eotaxin

Eotaxin (CCL11) binds CCR3 on eosinophils and is produced by airway epithelium and other cells in allergic disease. IL-8 (CXCL8) attracts neutrophils and MCP-1 (CCL2) attracts monocytes. Fractalkine is a membrane-bound chemokine that promotes adhesion of monocytes and T cells.

Option by option

  • A. Monocyte chemoattractant protein-1

    MCP-1 recruits monocytes and not eosinophils.

  • B. Interleukin-8

    Interleukin-8 is the main neutrophil chemoattractant.

  • C. Eotaxin (correct)

    Correct. Eotaxin is the eosinophil-selective chemokine acting through CCR3.

  • D. Fractalkine

    Fractalkine is membrane-bound and acts on monocytes, NK cells and T cells.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Eotaxin. Eotaxin (CCL11) binds CCR3 on eosinophils and is produced by airway epithelium and other cells in allergic disease.

Why is "Monocyte chemoattractant protein-1" not the answer?

MCP-1 recruits monocytes and not eosinophils.

Why is "Interleukin-8" not the answer?

Interleukin-8 is the main neutrophil chemoattractant.

Why is "Fractalkine" not the answer?

Fractalkine is membrane-bound and acts on monocytes, NK cells and T cells.

What concept does this question test?

It tests Inflammation and repair: eotaxin in Pathology. IL-8 (CXCL8) attracts neutrophils and MCP-1 (CCL2) attracts monocytes. Fractalkine is a membrane-bound chemokine that promotes adhesion of monocytes and T cells.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation and repair: eotaxin?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.