Neoplasia: myxoid liposarcoma: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Neoplasia: myxoid liposarcoma

Sample item

A 40-year-old has a deep thigh mass. Histology shows uniform round cells, a delicate plexiform capillary network and abundant myxoid stroma with lipoblasts. Which translocation is characteristic?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. t(12;16) producing FUS-DDIT3

Myxoid liposarcoma is defined by t(12;16)(q13;p11), fusing FUS with DDIT3 (CHOP). Well-differentiated and dedifferentiated liposarcoma instead show MDM2 and CDK4 amplification.

Option by option

  • A. t(11;22) producing EWSR1-FLI1

    EWSR1-FLI1 defines Ewing sarcoma.

  • B. t(X;18) producing SS18-SSX

    SS18-SSX defines synovial sarcoma.

  • C. t(12;16) producing FUS-DDIT3 (correct)

    Correct. FUS-DDIT3 defines myxoid (round cell) liposarcoma.

  • D. t(9;22) producing BCR-ABL

    BCR-ABL is the translocation of chronic myeloid leukaemia.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, t(12;16) producing FUS-DDIT3. Myxoid liposarcoma is defined by t(12;16)(q13;p11), fusing FUS with DDIT3 (CHOP).

Why is "t(11;22) producing EWSR1-FLI1" not the answer?

EWSR1-FLI1 defines Ewing sarcoma.

Why is "t(X;18) producing SS18-SSX" not the answer?

SS18-SSX defines synovial sarcoma.

Why is "t(9;22) producing BCR-ABL" not the answer?

BCR-ABL is the translocation of chronic myeloid leukaemia.

What concept does this question test?

It tests Neoplasia: myxoid liposarcoma in Pathology. Well-differentiated and dedifferentiated liposarcoma instead show MDM2 and CDK4 amplification.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neoplasia: myxoid liposarcoma?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.