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Psychiatry · Psychotic disorders: secondary negative symptoms
Sample itemA man with chronic schizophrenia on haloperidol appears expressionless, moves little and speaks rarely. He has cogwheel rigidity and a resting tremor, and his hallucinations are well controlled. What is the best next step?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Reduce the dose or add an anticholinergic, as this may be drug-induced parkinsonism
Extrapyramidal parkinsonism can mimic negative symptoms, giving masked facies, akinesia and poverty of speech. Rigidity and tremor point to a drug cause, so the dose should be lowered or an anticholinergic added, or the drug switched, rather than increased.
Option by option
A. Stop all medicines to assess his baseline
Stopping all medicines risks relapse of well-controlled psychosis.
B. Start a tricyclic antidepressant for apathy
A tricyclic would add anticholinergic effects but does not address the cause and may worsen psychosis.
C. Treat as primary negative symptoms and increase the haloperidol dose
Increasing haloperidol would worsen the parkinsonism and the apparent negative symptoms.
D. Reduce the dose or add an anticholinergic, as this may be drug-induced parkinsonism (correct)
Correct. Rigidity and tremor suggest drug-induced parkinsonism producing secondary negative symptoms.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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