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Psychiatry · Psychotic disorders: forced normalisation
Sample itemA man with long-standing temporal lobe epilepsy has his seizures controlled with a new anticonvulsant, and his EEG becomes normal. Within weeks he becomes suspicious, hears voices and shows disorganised behaviour while fully alert. Which concept best explains this?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Forced normalisation (alternative psychosis)
Forced normalisation, described by Landolt, is the emergence of psychosis when seizures are suppressed and the EEG normalises, with the psychosis improving if seizures return. Postictal psychosis follows a cluster of seizures after a lucid interval, which is not the sequence here.
Option by option
A. Postictal psychosis
Postictal psychosis follows a seizure cluster after a short lucid interval, not seizure suppression.
B. Forced normalisation (alternative psychosis) (correct)
Correct. Psychosis appearing as seizures stop and the EEG normalises is forced normalisation.
C. Primary schizophrenia unrelated to epilepsy
Attributing it to coincidental schizophrenia ignores the clear temporal link to seizure control.
D. Anticonvulsant-induced delirium
Delirium would show clouded consciousness, but he is fully alert.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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