Organic mental disorders: Wilson disease: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Psychiatry · Organic mental disorders: Wilson disease

Sample item

An 18-year-old has declining school performance, depression, dysarthria, tremor and abnormal liver enzymes. Which examination finding would best support the suspected diagnosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Kayser-Fleischer ring on slit-lamp examination

Wilson disease is an autosomal recessive disorder of copper metabolism (ATP7B), with copper deposited in the liver, basal ganglia and Descemet membrane of the cornea. Kayser-Fleischer rings are seen in nearly all patients with neuropsychiatric presentations, and ceruloplasmin is low.

Option by option

  • A. Kayser-Fleischer ring on slit-lamp examination (correct)

    Correct. Corneal copper deposition is characteristic of Wilson disease.

  • B. Lisch nodules of the iris

    Lisch nodules are iris hamartomas of neurofibromatosis type 1.

  • C. Argyll Robertson pupils

    Argyll Robertson pupils are a sign of neurosyphilis.

  • D. Bilateral papilloedema

    Papilloedema reflects raised intracranial pressure and is not typical here.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Psychiatry questions

Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is A, Kayser-Fleischer ring on slit-lamp examination. Wilson disease is an autosomal recessive disorder of copper metabolism (ATP7B), with copper deposited in the liver, basal ganglia and Descemet membrane of the cornea.

Why is "Lisch nodules of the iris" not the answer?

Lisch nodules are iris hamartomas of neurofibromatosis type 1.

Why is "Argyll Robertson pupils" not the answer?

Argyll Robertson pupils are a sign of neurosyphilis.

Why is "Bilateral papilloedema" not the answer?

Papilloedema reflects raised intracranial pressure and is not typical here.

What concept does this question test?

It tests Organic mental disorders: Wilson disease in Psychiatry. Kayser-Fleischer rings are seen in nearly all patients with neuropsychiatric presentations, and ceruloplasmin is low.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Organic mental disorders: Wilson disease?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.