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Psychiatry · Organic mental disorders: forced normalisation
Sample itemA man with refractory temporal lobe epilepsy becomes seizure-free after an anticonvulsant is added. Within weeks he becomes paranoid and hears voices, and an EEG now shows loss of his previous epileptiform discharges. Which diagnosis is most likely?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Alternative psychosis (forced normalisation)
Landolt's forced normalisation describes psychosis emerging when seizures are suppressed and the EEG normalises. It appears to be an inverse relationship between seizure control and psychiatric symptoms, and may resolve if seizures recur or the drug is changed.
Option by option
A. Postictal psychosis
Postictal psychosis follows a cluster of seizures after a lucid interval, not seizure freedom.
B. Chronic interictal psychosis of Slater
Interictal psychosis develops over years of epilepsy, without a link to seizure suppression.
C. Alternative psychosis (forced normalisation) (correct)
Correct. Psychosis emerges as seizures and EEG abnormalities are suppressed.
D. Acute alcohol withdrawal psychosis
There is no history of alcohol use or withdrawal to explain this.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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