Inflammation and repair: serotonin as mediator: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Inflammation and repair: serotonin as mediator

Sample item

Platelet dense granules release a preformed amine that increases vascular permeability and is a vasoconstrictor. Which mediator is this?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Serotonin

Serotonin is stored in platelet dense granules and enterochromaffin cells and released with platelet aggregation. It is a vasoactive amine causing vasoconstriction and increased permeability. Bradykinin is a plasma-derived peptide, not a platelet amine.

Option by option

  • A. Serotonin (correct)

    Correct. Platelet dense granules release serotonin.

  • B. Nitric oxide

    Nitric oxide is a gas produced by NOS and causes vasodilation.

  • C. Bradykinin

    Bradykinin is a plasma kinin produced from kininogen.

  • D. Prostacyclin

    Prostacyclin is synthesised by endothelium and inhibits platelets.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is A, Serotonin. Serotonin is stored in platelet dense granules and enterochromaffin cells and released with platelet aggregation.

Why is "Nitric oxide" not the answer?

Nitric oxide is a gas produced by NOS and causes vasodilation.

Why is "Bradykinin" not the answer?

Bradykinin is a plasma kinin produced from kininogen.

Why is "Prostacyclin" not the answer?

Prostacyclin is synthesised by endothelium and inhibits platelets.

What concept does this question test?

It tests Inflammation and repair: serotonin as mediator in Pathology. It is a vasoactive amine causing vasoconstriction and increased permeability. Bradykinin is a plasma-derived peptide, not a platelet amine.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation and repair: serotonin as mediator?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.