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Dermatology · Bacterial infections: Lyme disease
Sample itemA hiker returns with an expanding annular red patch with central clearing at the site of a tick bite, along with mild fever. What is the treatment of choice in an adult?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Oral doxycycline for 10 to 14 days
Erythema migrans of early Lyme disease is due to Borrelia burgdorferi from Ixodes ticks. Doxycycline is the first-line therapy and prevents later cardiac, neurological and joint disease.
Option by option
A. Oral acyclovir
Acyclovir targets herpesviruses and has no activity against spirochaetes.
B. Oral doxycycline for 10 to 14 days (correct)
Correct. Doxycycline treats early localised Lyme disease.
C. Oral fluconazole
Fluconazole treats fungi, which are not the cause.
D. Topical corticosteroid
Topical steroids would not treat the infection and could worsen it.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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