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Dermatology · Fungal infections: talaromycosis
Sample itemAn HIV patient from northeast India has fever and umbilicated papules on the face resembling molluscum. Biopsy shows intracellular yeasts that divide by fission with a central septum. What is the organism?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Talaromyces marneffei
Talaromyces (Penicillium) marneffei is a thermally dimorphic fungus endemic in Southeast Asia and Manipur, linked to bamboo rats. Treatment is amphotericin B followed by itraconazole.
Option by option
A. Candida albicans
Candida forms pseudohyphae.
B. Cryptococcus neoformans
Cryptococcus has a capsule and divides by budding.
C. Talaromyces marneffei (correct)
Correct. Fission yeasts with a central septum identify T. marneffei.
D. Histoplasma capsulatum
Histoplasma is a small budding yeast within macrophages.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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