Fungal infections: griseofulvin: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Fungal infections: griseofulvin

Sample item

Which statement about griseofulvin is correct?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. It is contraindicated in pregnancy and in porphyria

Griseofulvin disrupts the mitotic spindle by binding microtubules and is active only against dermatophytes. It is teratogenic, can precipitate porphyria and is best absorbed with a fatty meal.

Option by option

  • A. It is contraindicated in pregnancy and in porphyria (correct)

    Correct. Pregnancy and porphyria are contraindications.

  • B. It is better absorbed on an empty stomach

    Absorption improves with fatty meals, not an empty stomach.

  • C. It is active against Candida

    Griseofulvin has no activity against Candida.

  • D. It is applied topically for onychomycosis

    It is an oral drug and has poor penetration into nails.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is A, It is contraindicated in pregnancy and in porphyria. Griseofulvin disrupts the mitotic spindle by binding microtubules and is active only against dermatophytes.

Why is "It is better absorbed on an empty stomach" not the answer?

Absorption improves with fatty meals, not an empty stomach.

Why is "It is active against Candida" not the answer?

Griseofulvin has no activity against Candida.

Why is "It is applied topically for onychomycosis" not the answer?

It is an oral drug and has poor penetration into nails.

What concept does this question test?

It tests Fungal infections: griseofulvin in Dermatology. It is teratogenic, can precipitate porphyria and is best absorbed with a fatty meal.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Fungal infections: griseofulvin?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.