Fungal infections: chronic mucocutaneous candidiasis: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Fungal infections: chronic mucocutaneous candidiasis

Sample item

A child has persistent candidiasis of nails, skin and mouth, with hypoparathyroidism and Addison disease. Which gene is mutated?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. AIRE

APECED, or autoimmune polyendocrinopathy type 1, results from AIRE mutations and gives chronic mucocutaneous candidiasis with autoimmune endocrine failure. Antibodies to IL-17 and IL-22 contribute to the Candida susceptibility.

Option by option

  • A. AIRE (correct)

    Correct. AIRE mutation explains the combination.

  • B. STAT3 only

    STAT3 mutation causes hyper-IgE syndrome, which lacks endocrinopathy.

  • C. FOXP3

    FOXP3 mutation causes IPEX syndrome with enteropathy and diabetes.

  • D. CFTR

    CFTR mutation causes cystic fibrosis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is A, AIRE. APECED, or autoimmune polyendocrinopathy type 1, results from AIRE mutations and gives chronic mucocutaneous candidiasis with autoimmune endocrine failure.

Why is "STAT3 only" not the answer?

STAT3 mutation causes hyper-IgE syndrome, which lacks endocrinopathy.

Why is "FOXP3" not the answer?

FOXP3 mutation causes IPEX syndrome with enteropathy and diabetes.

Why is "CFTR" not the answer?

CFTR mutation causes cystic fibrosis.

What concept does this question test?

It tests Fungal infections: chronic mucocutaneous candidiasis in Dermatology. Antibodies to IL-17 and IL-22 contribute to the Candida susceptibility.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Fungal infections: chronic mucocutaneous candidiasis?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.