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Dermatology · Papulosquamous disorders: oral lichen planus
Sample itemA woman with erosive oral lichen planus has persistent ulcers. Which investigation is important and why?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Hepatitis C serology, because of the association
Oral lichen planus is associated with hepatitis C infection in some regions, and erosive disease carries a small risk of squamous cell carcinoma so persistent ulcers need follow-up and biopsy. Treatment is with potent topical steroids.
Option by option
A. Skin patch test for nickel only
Patch testing may be done for suspected lichenoid reactions to amalgam but is not the standard first step.
B. Urine porphyrins only
Porphyrins relate to blistering photosensitivity disorders.
C. Antinuclear antibody for lupus only
ANA is not the key investigation for lichen planus.
D. Hepatitis C serology, because of the association (correct)
Correct. Hepatitis C association warrants serology.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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