Connective tissue disease: dermatomyositis antibodies: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Connective tissue disease: dermatomyositis antibodies

Sample item

In an adult with dermatomyositis, which myositis-specific antibody is most strongly associated with underlying malignancy?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Anti-TIF1 gamma

Anti-TIF1 gamma (anti-p155) is associated with malignancy-associated dermatomyositis in adults, so age-appropriate cancer screening is needed. Anti-Mi-2 predicts a good prognosis, and anti-Jo-1 is linked to antisynthetase syndrome with interstitial lung disease.

Option by option

  • A. Anti-centromere

    Anti-centromere is associated with limited systemic sclerosis.

  • B. Anti-Jo-1

    Anti-Jo-1 is linked to interstitial lung disease and mechanic's hands.

  • C. Anti-Mi-2

    Anti-Mi-2 is linked to classic disease with good steroid response.

  • D. Anti-TIF1 gamma (correct)

    Correct. Anti-TIF1 gamma signals paraneoplastic disease.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is D, Anti-TIF1 gamma. Anti-TIF1 gamma (anti-p155) is associated with malignancy-associated dermatomyositis in adults, so age-appropriate cancer screening is needed.

Why is "Anti-centromere" not the answer?

Anti-centromere is associated with limited systemic sclerosis.

Why is "Anti-Jo-1" not the answer?

Anti-Jo-1 is linked to interstitial lung disease and mechanic's hands.

Why is "Anti-Mi-2" not the answer?

Anti-Mi-2 is linked to classic disease with good steroid response.

What concept does this question test?

It tests Connective tissue disease: dermatomyositis antibodies in Dermatology. Anti-Mi-2 predicts a good prognosis, and anti-Jo-1 is linked to antisynthetase syndrome with interstitial lung disease.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Connective tissue disease: dermatomyositis antibodies?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.