Leprosy: dapsone adverse effects: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Leprosy: dapsone adverse effects

Sample item

Before starting dapsone for leprosy, which enzyme deficiency should be considered because of the risk of haemolysis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Glucose-6-phosphate dehydrogenase

Dapsone is an oxidant drug that can cause dose-related haemolysis, especially in G6PD deficiency, and methaemoglobinaemia. Agranulocytosis and hypersensitivity are other adverse effects.

Option by option

  • A. Alpha-1 antitrypsin

    Alpha-1 antitrypsin deficiency is unrelated.

  • B. Pyruvate kinase

    Pyruvate kinase deficiency is not the classic dapsone risk.

  • C. Thiopurine methyltransferase

    TPMT deficiency matters for azathioprine.

  • D. Glucose-6-phosphate dehydrogenase (correct)

    Correct. G6PD deficiency predisposes to haemolysis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is D, Glucose-6-phosphate dehydrogenase. Dapsone is an oxidant drug that can cause dose-related haemolysis, especially in G6PD deficiency, and methaemoglobinaemia.

Why is "Alpha-1 antitrypsin" not the answer?

Alpha-1 antitrypsin deficiency is unrelated.

Why is "Pyruvate kinase" not the answer?

Pyruvate kinase deficiency is not the classic dapsone risk.

Why is "Thiopurine methyltransferase" not the answer?

TPMT deficiency matters for azathioprine.

What concept does this question test?

It tests Leprosy: dapsone adverse effects in Dermatology. Agranulocytosis and hypersensitivity are other adverse effects.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Leprosy: dapsone adverse effects?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.