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Dermatology · STI: early congenital syphilis
Sample itemA 3-week-old infant has persistent bloody nasal discharge, vesicobullous lesions on the palms and soles and hepatosplenomegaly. What is the likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Early congenital syphilis
Snuffles, palmoplantar bullae (pemphigus syphiliticus), hepatosplenomegaly and bone changes are features of early congenital syphilis. Treatment is intravenous aqueous penicillin G for 10 days.
Option by option
A. Staphylococcal scalded skin syndrome
SSSS spares the palms and soles in the typical form.
B. Congenital rubella
Congenital rubella causes cataract, deafness and heart defects.
C. Early congenital syphilis (correct)
Correct. This constellation indicates early congenital syphilis.
D. Neonatal herpes
Neonatal herpes has grouped vesicles and CNS disease without snuffles.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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