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Dermatology · Acne: monitoring isotretinoin
Sample itemWhich baseline and follow-up laboratory tests are advised in a patient on oral isotretinoin?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Fasting lipid profile and liver function tests
Isotretinoin can raise triglycerides and cholesterol and elevate transaminases, so fasting lipids and liver function are checked at baseline and during therapy. Pregnancy tests are needed in women of childbearing age.
Option by option
A. Blood cultures
Blood cultures are not needed.
B. Thyroid antibodies only
Thyroid antibodies are not needed.
C. Fasting lipid profile and liver function tests (correct)
Correct. Lipids and liver enzymes are monitored.
D. Serum uric acid only
Uric acid monitoring is not specific to isotretinoin.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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