Vascular disorders: Behcet disease: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Vascular disorders: Behcet disease

Sample item

A young man from the Silk Route region has recurrent oral aphthae, genital ulcers and uveitis. A needle prick on the forearm produces a pustule after 48 hours. What is this test and the associated HLA?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Pathergy test, with HLA-B51

Behcet disease is a variable vessel vasculitis with recurrent oral and genital ulcers, uveitis and skin lesions, and a positive pathergy reaction supports the diagnosis. HLA-B51 is the associated allele.

Option by option

  • A. Patch test, with HLA-DR3

    Patch tests detect contact allergens.

  • B. Mantoux test, with HLA-B57

    Mantoux tests detect tuberculin sensitivity.

  • C. Pathergy test, with HLA-B51 (correct)

    Correct. Pathergy and HLA-B51 are linked to Behcet disease.

  • D. Tzanck test, with HLA-B27

    Tzanck smear identifies herpetic giant cells and HLA-B27 relates to spondyloarthropathies.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is C, Pathergy test, with HLA-B51. Behcet disease is a variable vessel vasculitis with recurrent oral and genital ulcers, uveitis and skin lesions, and a positive pathergy reaction supports the diagnosis.

Why is "Patch test, with HLA-DR3" not the answer?

Patch tests detect contact allergens.

Why is "Mantoux test, with HLA-B57" not the answer?

Mantoux tests detect tuberculin sensitivity.

Why is "Tzanck test, with HLA-B27" not the answer?

Tzanck smear identifies herpetic giant cells and HLA-B27 relates to spondyloarthropathies.

What concept does this question test?

It tests Vascular disorders: Behcet disease in Dermatology. HLA-B51 is the associated allele.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vascular disorders: Behcet disease?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.