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ENT · Neck: Hodgkin lymphoma
Sample itemA 25-year-old has painless rubbery cervical lymphadenopathy, fever and night sweats. Which cell is diagnostic on histology?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Reed-Sternberg cell
Reed-Sternberg cells, binucleate owl-eye cells, are the diagnostic feature of Hodgkin lymphoma. Excision biopsy of the node is preferred over FNAC for lymphoma. Mikulicz cells are in rhinoscleroma and Langhans cells in tuberculosis.
Option by option
A. Reed-Sternberg cell (correct)
Correct. Reed-Sternberg cells define Hodgkin lymphoma.
B. Mikulicz cell
Mikulicz cells characterise rhinoscleroma.
C. Langhans giant cell
Langhans cells are seen in tuberculosis.
D. Aschoff cell
Aschoff cells are seen in rheumatic carditis.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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