Neck: hereditary paraganglioma: practice question

A ENT question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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ENT · Neck: hereditary paraganglioma

Sample item

Familial carotid body and glomus tumours are most commonly associated with mutations in which gene family?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Succinate dehydrogenase (SDH) genes

Hereditary head and neck paragangliomas are most often due to SDHD and other SDH subunit mutations, which are mitochondrial complex II genes. Genetic testing and family screening are advised. RET is linked to medullary thyroid carcinoma and phaeochromocytoma in MEN2.

Option by option

  • A. NF1 gene

    NF1 is associated with neurofibromas.

  • B. RET proto-oncogene

    RET mutations cause MEN 2.

  • C. BRCA genes

    BRCA genes are related to breast and ovarian cancers.

  • D. Succinate dehydrogenase (SDH) genes (correct)

    Correct. SDH mutations underlie familial paragangliomas.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this ENT question

What is the answer to this ENT question?

The best answer is D, Succinate dehydrogenase (SDH) genes. Hereditary head and neck paragangliomas are most often due to SDHD and other SDH subunit mutations, which are mitochondrial complex II genes.

Why is "NF1 gene" not the answer?

NF1 is associated with neurofibromas.

Why is "RET proto-oncogene" not the answer?

RET mutations cause MEN 2.

Why is "BRCA genes" not the answer?

BRCA genes are related to breast and ovarian cancers.

What concept does this question test?

It tests Neck: hereditary paraganglioma in ENT. Genetic testing and family screening are advised. RET is linked to medullary thyroid carcinoma and phaeochromocytoma in MEN2.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neck: hereditary paraganglioma?

Learn tuning fork results and audiogram patterns by sketching them. Then use the flashcards and the other ENT questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.