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OBG · Medical disorders in pregnancy: peripartum cardiomyopathy
Sample itemA woman presents with breathlessness 3 weeks after delivery. Echocardiography shows an ejection fraction of 30 per cent with no other cause. Which adjunct therapy has been studied specifically in this condition?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Bromocriptine
Peripartum cardiomyopathy presents with heart failure in the last month of pregnancy to 5 months postpartum with an EF below 45 per cent. Standard heart failure treatment is given (avoiding ACE inhibitors in pregnancy), and bromocriptine, which blocks prolactin and its cleaved 16 kDa fragment, may aid recovery. Anticoagulation is considered with a very low EF.
Option by option
A. Bromocriptine (correct)
Correct. Bromocriptine is used as a disease-specific adjunct.
B. Amiodarone
Amiodarone is not disease-specific therapy.
C. Levothyroxine
Levothyroxine does not treat this cardiomyopathy.
D. Methotrexate
Methotrexate has no role.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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