Medical disorders in pregnancy: malaria: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Medical disorders in pregnancy: malaria

Sample item

Under Indian national guidance, which regimen is recommended for uncomplicated Plasmodium falciparum malaria in the first trimester?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Quinine plus clindamycin

In the first trimester, quinine with clindamycin for 7 days is advised for uncomplicated falciparum malaria, while an artemisinin-based combination therapy (ACT) is used in the second and third trimesters. Primaquine and tetracyclines are contraindicated in pregnancy. Severe malaria is treated with IV artesunate in any trimester.

Option by option

  • A. Artemether-lumefantrine

    ACT is reserved for later trimesters in the national programme.

  • B. Primaquine

    Primaquine can cause haemolysis in a G6PD-deficient fetus and is contraindicated.

  • C. Quinine plus clindamycin (correct)

    Correct. This is the first trimester regimen.

  • D. Chloroquine plus tetracycline

    Tetracyclines are contraindicated in pregnancy.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is C, Quinine plus clindamycin. In the first trimester, quinine with clindamycin for 7 days is advised for uncomplicated falciparum malaria, while an artemisinin-based combination therapy (ACT) is used in the second and third trimesters.

Why is "Artemether-lumefantrine" not the answer?

ACT is reserved for later trimesters in the national programme.

Why is "Primaquine" not the answer?

Primaquine can cause haemolysis in a G6PD-deficient fetus and is contraindicated.

Why is "Chloroquine plus tetracycline" not the answer?

Tetracyclines are contraindicated in pregnancy.

What concept does this question test?

It tests Medical disorders in pregnancy: malaria in OBG. Primaquine and tetracyclines are contraindicated in pregnancy. Severe malaria is treated with IV artesunate in any trimester.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Medical disorders in pregnancy: malaria?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.