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OBG · Congenital infections: rubella
Sample itemRubella infection acquired in the first trimester is associated with which triad?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Cataract, sensorineural deafness and patent ductus arteriosus
Congenital rubella syndrome (Gregg's triad) consists of cataract, sensorineural deafness and cardiac defects (PDA, pulmonary stenosis). The risk of congenital defects is above 80 per cent when infection occurs before 12 weeks. There is no antiviral treatment, so prevention by immunising before pregnancy is the key.
Option by option
A. Cataract, sensorineural deafness and patent ductus arteriosus (correct)
Correct. This is the classic Gregg triad.
B. Microcephaly, limb hypoplasia and skin scarring
This pattern describes congenital varicella syndrome.
C. Hepatosplenomegaly, snuffles and bone lesions
This pattern describes congenital syphilis.
D. Hydrocephalus, chorioretinitis and intracranial calcification
This triad describes congenital toxoplasmosis.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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