Gynaecological endocrinology: Kallmann syndrome: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological endocrinology: Kallmann syndrome

Sample item

A tall 17-year-old girl with primary amenorrhoea, absent breast development and anosmia has low FSH, low LH and low oestradiol. What is the cause?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Isolated GnRH deficiency (Kallmann syndrome)

Kallmann syndrome results from failure of GnRH neurone migration, causing hypogonadotropic hypogonadism with anosmia or hyposmia. Treatment is pulsatile GnRH or gonadotrophins for fertility, and oestrogen for puberty.

Option by option

  • A. Isolated GnRH deficiency (Kallmann syndrome) (correct)

    Correct. Anosmia with low gonadotrophins indicates Kallmann syndrome.

  • B. Polycystic ovary syndrome

    PCOS shows normal puberty and high LH.

  • C. Gonadal dysgenesis

    Gonadal dysgenesis gives high gonadotrophins.

  • D. Mullerian agenesis

    Mullerian agenesis has normal breast development.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is A, Isolated GnRH deficiency (Kallmann syndrome). Kallmann syndrome results from failure of GnRH neurone migration, causing hypogonadotropic hypogonadism with anosmia or hyposmia.

Why is "Polycystic ovary syndrome" not the answer?

PCOS shows normal puberty and high LH.

Why is "Gonadal dysgenesis" not the answer?

Gonadal dysgenesis gives high gonadotrophins.

Why is "Mullerian agenesis" not the answer?

Mullerian agenesis has normal breast development.

What concept does this question test?

It tests Gynaecological endocrinology: Kallmann syndrome in OBG. Treatment is pulsatile GnRH or gonadotrophins for fertility, and oestrogen for puberty.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological endocrinology: Kallmann syndrome?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.