Gynaecological oncology: vaginal clear cell carcinoma: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological oncology: vaginal clear cell carcinoma

Sample item

In-utero exposure to which drug is associated with clear cell adenocarcinoma of the vagina?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Diethylstilboestrol

Daughters of women who took DES during pregnancy have a risk of clear cell adenocarcinoma of the vagina and cervix, and also Mullerian anomalies such as a T-shaped uterus. Adenosis is the precursor lesion.

Option by option

  • A. Diethylstilboestrol (correct)

    Correct. DES exposure is the known cause.

  • B. Warfarin

    Warfarin causes embryopathy.

  • C. Thalidomide

    Thalidomide causes limb defects.

  • D. Valproate

    Valproate causes neural tube defects.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is A, Diethylstilboestrol. Daughters of women who took DES during pregnancy have a risk of clear cell adenocarcinoma of the vagina and cervix, and also Mullerian anomalies such as a T-shaped uterus.

Why is "Warfarin" not the answer?

Warfarin causes embryopathy.

Why is "Thalidomide" not the answer?

Thalidomide causes limb defects.

Why is "Valproate" not the answer?

Valproate causes neural tube defects.

What concept does this question test?

It tests Gynaecological oncology: vaginal clear cell carcinoma in OBG. Adenosis is the precursor lesion.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological oncology: vaginal clear cell carcinoma?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.