Uvea: aniridia: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Uvea: aniridia

Sample item

A child with absent iris and sporadic aniridia is at risk of which tumour, and which chromosomal region is involved?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Wilms tumour, deletion of 11p13

WAGR syndrome has Wilms tumour, aniridia, genitourinary anomalies and mental retardation due to deletion at 11p13 including PAX6 and WT1. Such children need regular abdominal ultrasound.

Option by option

  • A. Wilms tumour, deletion of 11p13 (correct)

    Correct. Sporadic aniridia needs Wilms tumour surveillance.

  • B. Optic glioma, NF1

    NF1 gives Lisch nodules and optic glioma.

  • C. Retinoblastoma, deletion of 13q14

    13q14 deletion relates to retinoblastoma.

  • D. Neuroblastoma, MYCN amplification

    MYCN is in neuroblastoma, not aniridia.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is A, Wilms tumour, deletion of 11p13. WAGR syndrome has Wilms tumour, aniridia, genitourinary anomalies and mental retardation due to deletion at 11p13 including PAX6 and WT1.

Why is "Optic glioma, NF1" not the answer?

NF1 gives Lisch nodules and optic glioma.

Why is "Retinoblastoma, deletion of 13q14" not the answer?

13q14 deletion relates to retinoblastoma.

Why is "Neuroblastoma, MYCN amplification" not the answer?

MYCN is in neuroblastoma, not aniridia.

What concept does this question test?

It tests Uvea: aniridia in Ophthalmology. Such children need regular abdominal ultrasound.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Uvea: aniridia?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.