Uvea: coloboma: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Uvea: coloboma

Sample item

A child has a keyhole-shaped pupil with the defect located inferonasally. What is the embryological cause?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Incomplete closure of the embryonic fissure

Typical colobomas lie inferonasally because the embryonic fissure closes there last. They may involve iris, choroid and optic disc, and are associated with CHARGE syndrome.

Option by option

  • A. Persistent hyaloid artery

    Persistent hyaloid artery gives a Mittendorf dot or Bergmeister papilla.

  • B. Intrauterine rubella

    Rubella causes cataract and retinopathy.

  • C. Incomplete closure of the embryonic fissure (correct)

    Correct. Failed fissure closure gives typical colobomas.

  • D. Failure of the lens vesicle to form

    Failure of lens vesicle formation causes aphakia.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Ophthalmology questions

Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is C, Incomplete closure of the embryonic fissure. Typical colobomas lie inferonasally because the embryonic fissure closes there last.

Why is "Persistent hyaloid artery" not the answer?

Persistent hyaloid artery gives a Mittendorf dot or Bergmeister papilla.

Why is "Intrauterine rubella" not the answer?

Rubella causes cataract and retinopathy.

Why is "Failure of the lens vesicle to form" not the answer?

Failure of lens vesicle formation causes aphakia.

What concept does this question test?

It tests Uvea: coloboma in Ophthalmology. They may involve iris, choroid and optic disc, and are associated with CHARGE syndrome.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Uvea: coloboma?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.