Retina: Best disease: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Retina: Best disease

Sample item

A child with a normal ERG has a yolk-like macular lesion and an abnormal electro-oculogram. What is the finding in the EOG?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Reduced Arden ratio

Best vitelliform macular dystrophy affects the RPE and is characterised by a markedly reduced Arden ratio on EOG with normal ERG. It is autosomal dominant due to a BEST1 mutation.

Option by option

  • A. Raised Arden ratio

    The ratio falls, not rises.

  • B. Absent a-wave on ERG

    ERG is normal in Best disease.

  • C. Normal Arden ratio

    The EOG is abnormal.

  • D. Reduced Arden ratio (correct)

    Correct. EOG is abnormal while ERG is normal.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Ophthalmology questions

Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is D, Reduced Arden ratio. Best vitelliform macular dystrophy affects the RPE and is characterised by a markedly reduced Arden ratio on EOG with normal ERG.

Why is "Raised Arden ratio" not the answer?

The ratio falls, not rises.

Why is "Absent a-wave on ERG" not the answer?

ERG is normal in Best disease.

Why is "Normal Arden ratio" not the answer?

The EOG is abnormal.

What concept does this question test?

It tests Retina: Best disease in Ophthalmology. It is autosomal dominant due to a BEST1 mutation.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Retina: Best disease?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.