Antipsychotics: amisulpride: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antipsychotics: amisulpride

Sample item

A patient with predominantly negative symptoms of schizophrenia is given low-dose amisulpride. Its pharmacological property is:

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Selective D2/D3 antagonism with preferential limbic action

Amisulpride is a substituted benzamide that selectively blocks D2/D3 receptors, with presynaptic autoreceptor blockade at low doses enhancing dopamine release (used for negative symptoms and dysthymia). It raises prolactin markedly and is renally excreted.

Option by option

  • A. D2 partial agonism

    D2 partial agonism describes aripiprazole.

  • B. 5-HT3 antagonism

    5-HT3 antagonism describes ondansetron.

  • C. Strong H1 and alpha-1 blockade

    H1 and alpha-1 blockade describes quetiapine or chlorpromazine.

  • D. Selective D2/D3 antagonism with preferential limbic action (correct)

    Correct. It is a selective D2/D3 antagonist.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is D, Selective D2/D3 antagonism with preferential limbic action. Amisulpride is a substituted benzamide that selectively blocks D2/D3 receptors, with presynaptic autoreceptor blockade at low doses enhancing dopamine release (used for negative symptoms and dysthymia).

Why is "D2 partial agonism" not the answer?

D2 partial agonism describes aripiprazole.

Why is "5-HT3 antagonism" not the answer?

5-HT3 antagonism describes ondansetron.

Why is "Strong H1 and alpha-1 blockade" not the answer?

H1 and alpha-1 blockade describes quetiapine or chlorpromazine.

What concept does this question test?

It tests Antipsychotics: amisulpride in Psychiatry. It raises prolactin markedly and is renally excreted.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antipsychotics: amisulpride?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.