Antipsychotics: lurasidone: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antipsychotics: lurasidone

Sample item

Which statement about lurasidone is correct?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. It is approved for bipolar depression and should be taken with food

Lurasidone is an atypical antipsychotic with 5-HT7 and 5-HT2A antagonism and D2 antagonism, used in schizophrenia and bipolar depression. It should be taken with at least 350 kcal of food for absorption and has little weight gain.

Option by option

  • A. It is approved for bipolar depression and should be taken with food (correct)

    Correct. Lurasidone treats bipolar depression and needs food.

  • B. It is a first-generation drug causing severe EPS

    It is a second-generation agent.

  • C. It causes the highest weight gain of all atypicals

    It causes little weight gain.

  • D. It requires weekly blood counts

    Blood counts are required for clozapine, not lurasidone.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is A, It is approved for bipolar depression and should be taken with food. Lurasidone is an atypical antipsychotic with 5-HT7 and 5-HT2A antagonism and D2 antagonism, used in schizophrenia and bipolar depression.

Why is "It is a first-generation drug causing severe EPS" not the answer?

It is a second-generation agent.

Why is "It causes the highest weight gain of all atypicals" not the answer?

It causes little weight gain.

Why is "It requires weekly blood counts" not the answer?

Blood counts are required for clozapine, not lurasidone.

What concept does this question test?

It tests Antipsychotics: lurasidone in Psychiatry. It should be taken with at least 350 kcal of food for absorption and has little weight gain.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antipsychotics: lurasidone?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.