Antipsychotics: quetiapine: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antipsychotics: quetiapine

Sample item

Which atypical antipsychotic has approval for both acute mania and bipolar depression, and carries low EPS risk but marked sedation and weight gain?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Quetiapine

Quetiapine is licensed for schizophrenia, bipolar mania and bipolar depression. It has weak D2 binding and high H1 affinity, explaining the sedation and low EPS.

Option by option

  • A. Risperidone

    Risperidone is used for mania and psychosis but not approved for bipolar depression.

  • B. Haloperidol

    Haloperidol is used for mania but not bipolar depression and carries high EPS.

  • C. Amisulpride

    Amisulpride is used in schizophrenia and dysthymia at low doses.

  • D. Quetiapine (correct)

    Correct. Quetiapine is used across bipolar phases.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is D, Quetiapine. Quetiapine is licensed for schizophrenia, bipolar mania and bipolar depression.

Why is "Risperidone" not the answer?

Risperidone is used for mania and psychosis but not approved for bipolar depression.

Why is "Haloperidol" not the answer?

Haloperidol is used for mania but not bipolar depression and carries high EPS.

Why is "Amisulpride" not the answer?

Amisulpride is used in schizophrenia and dysthymia at low doses.

What concept does this question test?

It tests Antipsychotics: quetiapine in Psychiatry. It has weak D2 binding and high H1 affinity, explaining the sedation and low EPS.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antipsychotics: quetiapine?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.