Suicidology: clozapine: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Suicidology: clozapine

Sample item

Which antipsychotic has been shown to reduce suicidal behaviour in patients with schizophrenia or schizoaffective disorder?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Clozapine

In the InterSePT trial, clozapine reduced suicidal behaviour more than olanzapine, and it carries an indication for reducing suicide risk in schizophrenia. This is one reason to prefer it in high-risk patients.

Option by option

  • A. Clozapine (correct)

    Correct. Clozapine has evidence for reducing suicidality.

  • B. Chlorpromazine

    Chlorpromazine lacks such evidence.

  • C. Haloperidol

    Haloperidol lacks such evidence.

  • D. Trifluoperazine

    Trifluoperazine lacks such evidence.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is A, Clozapine. In the InterSePT trial, clozapine reduced suicidal behaviour more than olanzapine, and it carries an indication for reducing suicide risk in schizophrenia.

Why is "Chlorpromazine" not the answer?

Chlorpromazine lacks such evidence.

Why is "Haloperidol" not the answer?

Haloperidol lacks such evidence.

Why is "Trifluoperazine" not the answer?

Trifluoperazine lacks such evidence.

What concept does this question test?

It tests Suicidology: clozapine in Psychiatry. This is one reason to prefer it in high-risk patients.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Suicidology: clozapine?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.