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Radiology · Radiation effects: fetal exposure
Sample itemAt which period of gestation is the risk of major malformations from radiation greatest?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Organogenesis (about weeks 2 to 8 after conception)
Malformations are chiefly caused during organogenesis, and CNS effects are important during 8 to 15 weeks. Pre-implantation exposure follows an all-or-none pattern, with death or normal development. Deterministic fetal effects are not expected below about 100 mGy.
Option by option
A. Immediately before delivery
Delivery is too late for structural malformation.
B. Pre-implantation (first 10 days)
Pre-implantation shows an all-or-none effect.
C. Organogenesis (about weeks 2 to 8 after conception) (correct)
Correct. Organogenesis is the highest-risk period for malformations.
D. Third trimester
Third trimester carries less risk of malformation, though cancer risk persists.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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